Cialis helps to temporarily provide men with the ability to get and keep an erection by increasing blood flow to the penis. A man's erection depends on the body delivering - and trapping - the blood in the penis long enough to provide the stimulation and satisfaction for sexual activity. Cialis, in clinical trials, has proven to do this for men who suffer from mild to moderate ED.
The male organ contains two chambers - the corpora cavernosa - which runs the length of the organ. These chambers are filled with a spongy tissue containing smooth muscles, fibrous tissues, some spaces, veins and arteries. The urethra, which is the channel for both urine and ejaculation, runs along the underside of the chambers.
An erection begins with either mental or physical stimulation, or both. Impulses sent from the brain and the local nerves cause the this vein filled chamber to relax which allows an increased blood flow to the area. Obviously, this increase in blood expands the male organ and then the blood is trapped, which is what sustains the erection. The erection is not reversed until the organ contracts to stop the inflow of blood and opens the outflow channels, which then releases the blood.
Cialis works through its ability to help trap the blood flow through the inhibition of a substance called PDE5, which in turn stimulates the creation of a second substance cyclic GMP - cGMP - which is responsible for the relaxation of the muscles in this area causing an increase in the blood flow.
Primary U.S. clinical studies show "meaningful and statistically significant improvement" in the sexual functions of men after using a 20 mg dose of Cialis. These results held steady even with extended use. The efficacy and safety trials involved 402 men whose ages ranged from 27 to 87 years of age. Included in this group of ethnically diverse men were those who suffered in addition to impotence, diabetes, high blood pressure and other cardiovascular diseases. The majority of these men had experienced erectile dysfunction for a minimum of one year.Clinical trials conducted outside the United States revealed the same results. In these studies, the ages of the men ranged from 21 to 82 years, included men whose erectile difficulties stemmed from a variety of reasons, including organic and psychological.The minimum length of time a man had experience erectile dysfunction was one year.
The advantage of Cialis is the ability of the medication to linger in the man's system for up to 36 hours. This allows him and his partner to choose the proper time. The three major erectile dysfunction drugs on the market all work in a similar way. As with any medication, though, each person experiences different results with different drugs. Many men have switched to Cialis because Viagra or Levitra did not work well enough for them. Some men received good results with Viagra but switched to Cialis because of the larger window of opportunity - the advantage of having the ability to make love in a time frame as long as 36 hours.
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Erectile dysfunction
Erectile dysfunction (ED) affects the lives of many middle-aged men and their partners. The term erectile dysfunction covers a range of disorders, but usually refers to the inability to obtain an adequate erection for satisfactory sexual activity.
Although erectile dysfunction, formerly called impotence, is more common in men older than 65, it can occur at any age. An occasional episode of erectile dysfunction happens to most men and is normal. As men age, it's also normal to experience changes in erectile function. Erections may take longer to develop, may not be as rigid or may require more direct stimulation to be achieved. Men may also notice that orgasms are less intense, the volume of ejaculate is reduced and recovery time increases between erections. Erectile dysfunction may also be a sign of a physical or emotional problem that requires treatment.
Erectile dysfunction was once a taboo subject, but more men are seeking help. Doctors are gaining a better understanding of what causes erectile dysfunction and are finding new and better treatments.
This Website discusses all about erectile dysfunction, physiology of the normal erection and the pathophysiology, and treatment of ED.
What is Erectile Dysfunction?
Erectile dysfunction or impotence is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis for satisfactory sexual intercourse regardless of the capability of ejaculation. There are various underlying causes, such as diabetes, many of which are medically reversible.
The causes may be physiological or psychological. Psychological impotence can often be helped by almost anything that the patient believes in; there is a very strong placebo effect.
Due to its embarrassing nature and the shame felt by sufferers, the subject was taboo for a long time, and is the subject of many urban legends. Folk remedies have long been advocated, with some being advertised widely since the 1930s. The introduction of perhaps the first pharmacologically effective remedy for impotence, sildenafil (trade name Viagra), in the 1990s caused a wave of public attention, propelled in part by the news-worthiness of stories about it and heavy advertising.
The Latin term impotentia coeundi describes simple inability to insert the penis into the vagina. It is now mostly replaced by more precise terms.
Signs and symptoms:
Erectile dysfunction is characterized by the inability to maintain erection. Normal erections during sleep and in the early morning suggest a psychogenic cause, while loss of these erections may signify underlying disease, often cardiovascular in origin. Other things leading to erectile dysfunction are diabetes mellitus (causing neuropathy) or hypogonadism (decreased testosterone levels due to disease affecting the testicles or the pituitary gland).
Here are some causes of Erectile Dysfunction:
* Arousal: The first step is sexual arousal, which men obtain from the senses of sight, touch, hearing and smell, and from thoughts.
* Nervous system response: The brain communicates the sexual excitation to the body's nervous system, which activates increased blood flow to the penis.
* Blood vessel response:. A relaxing action occurs in the blood vessels that supply the penis, allowing more blood to flow into the shafts that produce the erection.
Physiology of normal erections:
Penile erections involve an integration of complex physiologic processes involving the CNS, peripheral nervous system, and hormonal and vascular systems. Any abnormality involving these systems, whether from medication or disease, has a significant impact on the ability to develop and sustain an erection, ejaculate, and experience orgasm. Tumescence, the vascular filling of the cavernous bodies, relies on neural and hormonal mechanisms operating at various levels of the neural axis. This is unique among visceral functions because it requires central neurological input.
Andersson et al summarized some of the information related to the pathways involved in erectile function. The degree of contraction of corpus cavernosal smooth muscle determines the functional state of the penis. The balance between contraction and relaxation is controlled by central and peripheral factors that involve many transmitters and transmitter systems. At the cellular level, smooth muscle relaxation occurs following the release of acetylcholine from the parasympathetic nerves.
Pathophysiology of erectile dysfunction:
Erectile Dysfunction is essentially a vascular disease. It is often associated with other vascular diseases and conditions such as diabetes, hypertension, and coronary artery disease. Other conditions associated with Erectile Dysfunction include neurologic disorders, endocrinopathies, benign prostatic hyperplasia, and depression. Conditions associated with reduced nerve and endothelium function, such as aging, hypertension, smoking, hypercholesterolemia, and diabetes, alter the balance between contraction and relaxation factors. These conditions cause circulatory and structural changes in penile tissues, resulting in arterial insufficiency and defective smooth muscle relaxation. In some patients, sexual dysfunction may be the presenting symptom of these disorders.
Treatment:
Sildenafil Citrate is the way to treat Erectile Dysfunction. Generic Viagra contains sildenafil citrate and contains same ingredients like branded drug.
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