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Clopidogrel is used for:

Reducing the risk of stroke or heart attack in patients who have already had a heart attack or stroke, or have other circulatory problems due to narrowing and hardening of the arteries. It also may be used for other conditions as determined by your doctor.

Clopidogrel is a platelet aggregation inhibitor. It works by slowing or stopping platelets from sticking to blood vessel walls or injured tissues.

Do NOT use Clopidogrel if:

  • you are allergic to any ingredient in Clopidogrel
  • you have an active bleeding disorder, such as stomach ulcer or bleeding in the brain

Contact your doctor or health care provider right away if any of these apply to you.

Before using Clopidogrel :

Some medical conditions may interact with Clopidogrel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have bone marrow disease
  • if you have increased risk of bleeding because of trauma or surgery, including dental surgery
  • if you have liver or kidney problems

Some MEDICINES MAY INTERACT with Clopidogrel. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Oral anticoagulants (eg, warfarin) or NSAIDs (eg, aspirin, ibuprofen) because the risk of side effects, including the risk of bleeding, may be increased by Clopidogrel

This may not be a complete list of all interactions that may occur. Ask your health care provider if Clopidogrel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Clopidogrel :

Use Clopidogrel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Clopidogrel by mouth with or without food.
  • Clopidogrel may need to be stopped if you are going to have surgery. Be sure to discuss this with your doctor or dentist.
  • If you miss a dose of Clopidogrel , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Clopidogrel.

Important safety information:

  • This medicine may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Clopidogrel with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Clopidogrel may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Tell your doctor or dentist that you take Clopidogrel before you receive any medical or dental care, emergency care, or surgery.
  • Clopidogrel should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clopidogrel while you are pregnant. It is unknown if Clopidogrel is found in breast milk. Do not breast-feed while taking Clopidogrel.

Possible side effects of Clopidogrel :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abdominal pain; back pain; bronchitis; bruising; constipation; coughing; depression; diarrhea; dizziness; flu-like symptoms; headache; indigestion; itching; joint pain; nausea; nosebleed; pain; rash; runny nose; swelling; tiredness; upper respiratory tract infection; urinary tract infection.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding in the eye; change in vision; chest pain; difficulty breathing; discoloration of urine or stools, including black, tarry stools; excessive bleeding from cuts; increased bleeding; increased menstrual bleeding; pale skin; seizures; severe, persistent headache; sore throat or fever; speech problems; unexplained vaginal bleeding; unusual bleeding from gums when brushing; unusual bruising; weakness; yellowing of skin/eyes.

What is the shelf life of the pills?

  • The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.

Everything is fine - thnxs for good service and hope we'll meet on line again.

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Erectile dysfunction

Erectile dysfunction (ED) affects the lives of many middle-aged men and their partners. The term erectile dysfunction covers a range of disorders, but usually refers to the inability to obtain an adequate erection for satisfactory sexual activity. Although erectile dysfunction, formerly called impotence, is more common in men older than 65, it can occur at any age. An occasional episode of erectile dysfunction happens to most men and is normal. As men age, it's also normal to experience changes in erectile function. Erections may take longer to develop, may not be as rigid or may require more direct stimulation to be achieved. Men may also notice that orgasms are less intense, the volume of ejaculate is reduced and recovery time increases between erections. Erectile dysfunction may also be a sign of a physical or emotional problem that requires treatment.

Erectile dysfunction was once a taboo subject, but more men are seeking help. Doctors are gaining a better understanding of what causes erectile dysfunction and are finding new and better treatments.

This Website discusses all about erectile dysfunction, physiology of the normal erection and the pathophysiology, and treatment of ED.

What is Erectile Dysfunction?

Erectile dysfunction or impotence is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis for satisfactory sexual intercourse regardless of the capability of ejaculation. There are various underlying causes, such as diabetes, many of which are medically reversible.

The causes may be physiological or psychological. Psychological impotence can often be helped by almost anything that the patient believes in; there is a very strong placebo effect.

Due to its embarrassing nature and the shame felt by sufferers, the subject was taboo for a long time, and is the subject of many urban legends. Folk remedies have long been advocated, with some being advertised widely since the 1930s. The introduction of perhaps the first pharmacologically effective remedy for impotence, sildenafil (trade name Viagra), in the 1990s caused a wave of public attention, propelled in part by the news-worthiness of stories about it and heavy advertising.

The Latin term impotentia coeundi describes simple inability to insert the penis into the vagina. It is now mostly replaced by more precise terms.

Signs and symptoms:

Erectile dysfunction is characterized by the inability to maintain erection. Normal erections during sleep and in the early morning suggest a psychogenic cause, while loss of these erections may signify underlying disease, often cardiovascular in origin. Other things leading to erectile dysfunction are diabetes mellitus (causing neuropathy) or hypogonadism (decreased testosterone levels due to disease affecting the testicles or the pituitary gland).

Here are some causes of Erectile Dysfunction:

* Arousal: The first step is sexual arousal, which men obtain from the senses of sight, touch, hearing and smell, and from thoughts.

* Nervous system response: The brain communicates the sexual excitation to the body's nervous system, which activates increased blood flow to the penis.

* Blood vessel response:. A relaxing action occurs in the blood vessels that supply the penis, allowing more blood to flow into the shafts that produce the erection.

Physiology of normal erections:

Penile erections involve an integration of complex physiologic processes involving the CNS, peripheral nervous system, and hormonal and vascular systems. Any abnormality involving these systems, whether from medication or disease, has a significant impact on the ability to develop and sustain an erection, ejaculate, and experience orgasm. Tumescence, the vascular filling of the cavernous bodies, relies on neural and hormonal mechanisms operating at various levels of the neural axis. This is unique among visceral functions because it requires central neurological input.

Andersson et al summarized some of the information related to the pathways involved in erectile function. The degree of contraction of corpus cavernosal smooth muscle determines the functional state of the penis. The balance between contraction and relaxation is controlled by central and peripheral factors that involve many transmitters and transmitter systems. At the cellular level, smooth muscle relaxation occurs following the release of acetylcholine from the parasympathetic nerves.

Pathophysiology of erectile dysfunction:

Erectile Dysfunction is essentially a vascular disease. It is often associated with other vascular diseases and conditions such as diabetes, hypertension, and coronary artery disease. Other conditions associated with Erectile Dysfunction include neurologic disorders, endocrinopathies, benign prostatic hyperplasia, and depression. Conditions associated with reduced nerve and endothelium function, such as aging, hypertension, smoking, hypercholesterolemia, and diabetes, alter the balance between contraction and relaxation factors. These conditions cause circulatory and structural changes in penile tissues, resulting in arterial insufficiency and defective smooth muscle relaxation. In some patients, sexual dysfunction may be the presenting symptom of these disorders.

Treatment:

Sildenafil Citrate is the way to treat Erectile Dysfunction. Generic Viagra contains sildenafil citrate and contains same ingredients like branded drug.

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