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Promethazine is used for:
Relieving allergy symptoms, including hives and nasal congestion. It is used to prevent and control pain and nausea during and after surgery. It is also used to help produce light sleep, and for the prevention of motion sickness. Promethazine is not to be used to treat asthma. It may also be used for other conditions as determined by your doctor.
Promethazine is a phenothiazine antihistamine. It works by blocking the sights where histamine acts.
Do NOT use Promethazine if:
you are allergic to any ingredient in Promethazine
you have a severe central nervous system depression or are in a coma
you are also taking astemizole, cisapride, terfenadine, or tramadol
Contact your doctor or health care provider right away if any of these apply to you.
Before using Promethazine:
Some medical conditions may interact with Promethazine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, plan to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines or other substances
if you have nervous system problems, bone marrow depression, heart problems, a blood disease, glaucoma, increased eye pressure, low blood pressure, liver problems, prostate problems, Parkinson disease, seizures, or Reye syndrome
if you regularly consume large amounts of alcohol
Some MEDICINES MAY INTERACT with Promethazine. Tell your health care provider if you are taking any other medicines, especially any of the following:
Charcoal or lithium because the effectiveness of Promethazine may be decreased
Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), astemizole, cisapride, general anesthetics (eg, thiopental), methyldopa, terfenadine, or tramadol because side effects such as low blood pressure and seizures may occur
ACE inhibitors (eg, enalapril), haloperidol, lithium, meperidine, metrizamide, monoamine oxidase (MAO) inhibitors (eg, phenelzine), naltrexone, polypeptide antibiotics (eg, actinomycin), or trazodone because the actions and side effects of these medicines may be increased
Bromocriptine, epinephrine, levodopa, or pergolide because the effectiveness of these medicines may be decreased
This may not be a complete list of all interactions that may occur. Ask your health care provider if Promethazine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Promethazine:
Use Promethazine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Promethazine may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
If you are using Promethazine for motion sickness, take a dose at least 30 to 60 minutes before you begin traveling.
If you miss a dose of Promethazine and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to you regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Promethazine.
Important safety information:
Promethazine may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Promethazine. Using Promethazine alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other
potentially dangerous tasks.
Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Promethazine. Promethazine will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
Neuroleptic malignant syndrome (NMS) is a potentially deadly syndrome associated with Promethazine. Symptoms include increased body heat; muscle rigidness; altered mental abilities, including lack of response to your surroundings; irregular pulse and blood pressure; increased heart rate; sweating;
irregular heart rhythm. Contact your doctor at once if any of these
symptoms occur.
Promethazine may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Promethazine. Use a sunscreen or protective clothing if you must be outside for a prolonged period.
Use extreme caution when using Promethazine in the ELDERLY as they may be more sensitive to the effects of this medicine.
Promethazine should not be used in CHILDREN under 2 years of age. Serious, and sometimes fatal, side effects (difficult or slowed breathing, drowsiness leading to coma) have occurred when Promethazine has been used in children in this age group. Promethazine should also be used with extreme caution
in children 2 years of age and older. The lowest effective dose should be
used in children 2 years of age and older.
If you are pregnant or plan on becoming pregnant, discuss with your doctor the benefits and risks of using Promethazine during pregnancy. Promethazine is excreted in breast milk. If you are or will be breast-feeding while you are using Promethazine, check with your doctor or pharmacist to discuss
the risks to your baby.
Possible side effects of Promethazine:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); sensitivity to light; uncontrolled muscle movements; yellowing of skin or eyes.
What is the shelf life of the pills?
The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
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Erectile dysfunction
Erectile dysfunction (ED) affects the lives of many middle-aged men and their partners. The term erectile dysfunction covers a range of disorders, but usually refers to the inability to obtain an adequate erection for satisfactory sexual activity.
Although erectile dysfunction, formerly called impotence, is more common in men older than 65, it can occur at any age. An occasional episode of erectile dysfunction happens to most men and is normal. As men age, it's also normal to experience changes in erectile function. Erections may take longer to develop, may not be as rigid or may require more direct stimulation to be achieved. Men may also notice that orgasms are less intense, the volume of ejaculate is reduced and recovery time increases between erections. Erectile dysfunction may also be a sign of a physical or emotional problem that requires treatment.
Erectile dysfunction was once a taboo subject, but more men are seeking help. Doctors are gaining a better understanding of what causes erectile dysfunction and are finding new and better treatments.
This Website discusses all about erectile dysfunction, physiology of the normal erection and the pathophysiology, and treatment of ED.
What is Erectile Dysfunction?
Erectile dysfunction or impotence is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis for satisfactory sexual intercourse regardless of the capability of ejaculation. There are various underlying causes, such as diabetes, many of which are medically reversible.
The causes may be physiological or psychological. Psychological impotence can often be helped by almost anything that the patient believes in; there is a very strong placebo effect.
Due to its embarrassing nature and the shame felt by sufferers, the subject was taboo for a long time, and is the subject of many urban legends. Folk remedies have long been advocated, with some being advertised widely since the 1930s. The introduction of perhaps the first pharmacologically effective remedy for impotence, sildenafil (trade name Viagra), in the 1990s caused a wave of public attention, propelled in part by the news-worthiness of stories about it and heavy advertising.
The Latin term impotentia coeundi describes simple inability to insert the penis into the vagina. It is now mostly replaced by more precise terms.
Signs and symptoms:
Erectile dysfunction is characterized by the inability to maintain erection. Normal erections during sleep and in the early morning suggest a psychogenic cause, while loss of these erections may signify underlying disease, often cardiovascular in origin. Other things leading to erectile dysfunction are diabetes mellitus (causing neuropathy) or hypogonadism (decreased testosterone levels due to disease affecting the testicles or the pituitary gland).
Here are some causes of Erectile Dysfunction:
* Arousal: The first step is sexual arousal, which men obtain from the senses of sight, touch, hearing and smell, and from thoughts.
* Nervous system response: The brain communicates the sexual excitation to the body's nervous system, which activates increased blood flow to the penis.
* Blood vessel response:. A relaxing action occurs in the blood vessels that supply the penis, allowing more blood to flow into the shafts that produce the erection.
Physiology of normal erections:
Penile erections involve an integration of complex physiologic processes involving the CNS, peripheral nervous system, and hormonal and vascular systems. Any abnormality involving these systems, whether from medication or disease, has a significant impact on the ability to develop and sustain an erection, ejaculate, and experience orgasm. Tumescence, the vascular filling of the cavernous bodies, relies on neural and hormonal mechanisms operating at various levels of the neural axis. This is unique among visceral functions because it requires central neurological input.
Andersson et al summarized some of the information related to the pathways involved in erectile function. The degree of contraction of corpus cavernosal smooth muscle determines the functional state of the penis. The balance between contraction and relaxation is controlled by central and peripheral factors that involve many transmitters and transmitter systems. At the cellular level, smooth muscle relaxation occurs following the release of acetylcholine from the parasympathetic nerves.
Pathophysiology of erectile dysfunction:
Erectile Dysfunction is essentially a vascular disease. It is often associated with other vascular diseases and conditions such as diabetes, hypertension, and coronary artery disease. Other conditions associated with Erectile Dysfunction include neurologic disorders, endocrinopathies, benign prostatic hyperplasia, and depression. Conditions associated with reduced nerve and endothelium function, such as aging, hypertension, smoking, hypercholesterolemia, and diabetes, alter the balance between contraction and relaxation factors. These conditions cause circulatory and structural changes in penile tissues, resulting in arterial insufficiency and defective smooth muscle relaxation. In some patients, sexual dysfunction may be the presenting symptom of these disorders.
Treatment:
Sildenafil Citrate is the way to treat Erectile Dysfunction. Generic Viagra contains sildenafil citrate and contains same ingredients like branded drug.
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