Why are generic pills cheaper than the brand name ones?
The principal reason for the reduced price of generic medicines is that the creation of the generic drug runs up less cost and therefore a lower price can be offered and still maintain profitability.
Manufacturers of generic drugs are mainly able to avoid the following three costs that brand name pharmaceutical companies incur: (1) costs associated with the research and development of the drug; (2) costs associated obtaining regulatory approval (i.e. proving safety and efficacy of a drug); and (3) marketing costs.
First, Generic manufacturers do not incur the cost of drug discovery and instead reverse-engineer existing brand name drugs to allow them to manufacture bioequivalent versions.
Second, generic manufacturers do not bear the burden of proving the safety and efficacy of the drugs through clinical trials - rather, generic manufacturers must prove the generic drug’s bioequivalancy to the existing drug.
Third, these companies receive the large benefit of the marketing and advertising that goes into pushing the innovator drug. The brand name drug has to prove itself in the eyes of the consumer, generic ones do not. The drugs that generic manufacturers are selling have been on the market for usually a decade or more and do not need additional advertising. For the same reason, generic manufacturers also do not give away sample doses to promote their products. The significant research, development and marketing costs incurred by the large pharmaceutical companies in introducing a new drug to the market is often cited as the reason for the high cost of new agents - they wish to recover these costs before the patent expires. Generic manufacturers do not incur these costs, with bioequivalence testing and manufacturing costing relatively little, and are able to charge significantly less than the brand.
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Ofloxacin is used for:
Treating mild to moderate infections caused by certain bacteria.
Ofloxacin is a fluoroquinolone antibiotic. It kills sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.
Do NOT use Ofloxacin if:
you are allergic to any ingredient in Ofloxacin
you are allergic to any other fluoroquinolone antibiotic (eg, ciprofloxacin)
you are taking nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) or typhoid oral vaccine
Contact your doctor or health care provider right away if any of these apply to you.
Before using Ofloxacin :
Some medical conditions may interact with Ofloxacin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, plan to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have diabetes
if you have heart problems, including irregular heartbeat; liver or kidney disease; or low potassium levels
if you have Alzheimer disease, hardening in the arteries in the brain, seizures, increased pressure on the brain, or another central nervous system disorder
if you have tendonitis
if your skin is sensitive to sunlight
Some MEDICINES MAY INTERACT with Ofloxacin. Tell your health care provider if you are taking any other medicines, especially any of the following:
Foscarnet, NSAIDs (eg, ibuprofen), or tramadol because the risk of seizures may be increased
Anticoagulants (eg, warfarin), procainamide, or theophylline because the side effects of these medicines may be increased
Live typhoid vaccine because the effectiveness of the vaccine may be decreased
Aluminum salts (eg, aluminum hydroxide), iron salts (oral) (eg, ferrous sulfate), or magnesium salts (eg, magnesium hydroxide) because the effectiveness of Ofloxacin is decreased. Take ofloxacin 2 hours before or 2 hours after these medicines to offset this effect.
This may not be a complete list of all interactions that may occur. Ask your health care provider if Ofloxacin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Ofloxacin :
Use Ofloxacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ofloxacin may be taken with food or on an empty stomach.
Drink a full glass of water with each dose. Drink several glasses of water daily, unless otherwise instructed by your doctor.
Do not drink milk or eat dairy products, or take antacids, sucralfate, or vitamins within 2 hours before or after taking Ofloxacin.
Ofloxacin works best if it is taken at the same time each day.
If you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Ofloxacin.
Important safety information:
Ofloxacin may cause dizziness, drowsiness, or lightheadedness. Use caution when driving or performing other tasks requiring alertness, coordination, or physical dexterity.
Ofloxacin may cause increased sensitivity to sunlight. Avoid prolonged exposure to the sun or other ultraviolet (UV) light (eg, tanning beds). Use sunscreens and wear protective clothing if you must be outside for a prolonged period of time.
Diabetic patients should monitor their blood sugar regularly while taking Ofloxacin with an antidiabetic medicine. Talk with your doctor at once if a reaction caused by low blood sugar occurs.
Notify your dentist or doctor that you are taking Ofloxacin before you have any dental work or surgery.
Long-term or repeated use of Ofloxacin may cause a second infection. You may need to start another medication to treat the second infection. Contact your doctor if signs of a second infection occur.
If you experience pain or inflammation, or rupture a tendon during or shortly after taking ofloxacin, contact your health care provider immediately.
If severe diarrhea, stomach cramps/pain, or bloody stools occur, contact your doctor at once. This could be a sign of a serious side effect that needs immediate medical attention. Do not treat diarrhea without consulting your doctor.
It is important to use Ofloxacin for the full course of treatment. Failure to do so may decrease the effectiveness of this treatment and may increase the risk that the bacteria will no longer be sensitive to Ofloxacin and it will not be able to be treated by this or certain other antibacterial
medicines in the future.
LAB TESTS, such as kidney function tests, may be needed to monitor your condition. Be sure to keep all lab appointments.
Ofloxacin is not recommended for use in CHILDREN younger than 18 years of age; safety and effectiveness in this age group have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Ofloxacin during pregnancy. Ofloxacin is excreted in breast milk. Do not breast-feed while taking Ofloxacin.
Possible side effects of Ofloxacin :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Diarrhea; dizziness; headache; loss of appetite; nausea; nervousness; sensitivity to sunlight; trouble sleeping; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; anxiety; bizarre behavior; bloody stools; confusion; convulsions; dark urine; depression; diarrhea (severe or continuing); difficulty swallowing; excessive urination, thirst, or hunger;
fatigue; fever; hallucinations; hoarseness; increased pressure within the head;
joint or muscle pain or swelling; lightheadedness; loss of consciousness;
nervousness; nightmares; pale stools; paranoia; rapid heartbeat; rash, skin
burning, redness, swelling, blisters, itching, or skin inflammation;
restlessness; seizures; shock (pale skin); sleeplessness; stomach pain/cramps;
suicidal thoughts; tendon pain, inflammation, or swelling; tightness of the
throat; tingling; tremors; urination problems; vaginal irritation or discharge;
yellowing of skin or eyes.
What is the shelf life of the pills?
The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
You must set the tan_unit_111.txt file to be writable (check file name as also).
Erectile dysfunction
Erectile dysfunction (ED) affects the lives of many middle-aged men and their partners. The term erectile dysfunction covers a range of disorders, but usually refers to the inability to obtain an adequate erection for satisfactory sexual activity.
Although erectile dysfunction, formerly called impotence, is more common in men older than 65, it can occur at any age. An occasional episode of erectile dysfunction happens to most men and is normal. As men age, it's also normal to experience changes in erectile function. Erections may take longer to develop, may not be as rigid or may require more direct stimulation to be achieved. Men may also notice that orgasms are less intense, the volume of ejaculate is reduced and recovery time increases between erections. Erectile dysfunction may also be a sign of a physical or emotional problem that requires treatment.
Erectile dysfunction was once a taboo subject, but more men are seeking help. Doctors are gaining a better understanding of what causes erectile dysfunction and are finding new and better treatments.
This Website discusses all about erectile dysfunction, physiology of the normal erection and the pathophysiology, and treatment of ED.
What is Erectile Dysfunction?
Erectile dysfunction or impotence is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis for satisfactory sexual intercourse regardless of the capability of ejaculation. There are various underlying causes, such as diabetes, many of which are medically reversible.
The causes may be physiological or psychological. Psychological impotence can often be helped by almost anything that the patient believes in; there is a very strong placebo effect.
Due to its embarrassing nature and the shame felt by sufferers, the subject was taboo for a long time, and is the subject of many urban legends. Folk remedies have long been advocated, with some being advertised widely since the 1930s. The introduction of perhaps the first pharmacologically effective remedy for impotence, sildenafil (trade name Viagra), in the 1990s caused a wave of public attention, propelled in part by the news-worthiness of stories about it and heavy advertising.
The Latin term impotentia coeundi describes simple inability to insert the penis into the vagina. It is now mostly replaced by more precise terms.
Signs and symptoms:
Erectile dysfunction is characterized by the inability to maintain erection. Normal erections during sleep and in the early morning suggest a psychogenic cause, while loss of these erections may signify underlying disease, often cardiovascular in origin. Other things leading to erectile dysfunction are diabetes mellitus (causing neuropathy) or hypogonadism (decreased testosterone levels due to disease affecting the testicles or the pituitary gland).
Here are some causes of Erectile Dysfunction:
* Arousal: The first step is sexual arousal, which men obtain from the senses of sight, touch, hearing and smell, and from thoughts.
* Nervous system response: The brain communicates the sexual excitation to the body's nervous system, which activates increased blood flow to the penis.
* Blood vessel response:. A relaxing action occurs in the blood vessels that supply the penis, allowing more blood to flow into the shafts that produce the erection.
Physiology of normal erections:
Penile erections involve an integration of complex physiologic processes involving the CNS, peripheral nervous system, and hormonal and vascular systems. Any abnormality involving these systems, whether from medication or disease, has a significant impact on the ability to develop and sustain an erection, ejaculate, and experience orgasm. Tumescence, the vascular filling of the cavernous bodies, relies on neural and hormonal mechanisms operating at various levels of the neural axis. This is unique among visceral functions because it requires central neurological input.
Andersson et al summarized some of the information related to the pathways involved in erectile function. The degree of contraction of corpus cavernosal smooth muscle determines the functional state of the penis. The balance between contraction and relaxation is controlled by central and peripheral factors that involve many transmitters and transmitter systems. At the cellular level, smooth muscle relaxation occurs following the release of acetylcholine from the parasympathetic nerves.
Pathophysiology of erectile dysfunction:
Erectile Dysfunction is essentially a vascular disease. It is often associated with other vascular diseases and conditions such as diabetes, hypertension, and coronary artery disease. Other conditions associated with Erectile Dysfunction include neurologic disorders, endocrinopathies, benign prostatic hyperplasia, and depression. Conditions associated with reduced nerve and endothelium function, such as aging, hypertension, smoking, hypercholesterolemia, and diabetes, alter the balance between contraction and relaxation factors. These conditions cause circulatory and structural changes in penile tissues, resulting in arterial insufficiency and defective smooth muscle relaxation. In some patients, sexual dysfunction may be the presenting symptom of these disorders.
Treatment:
Sildenafil Citrate is the way to treat Erectile Dysfunction. Generic Viagra contains sildenafil citrate and contains same ingredients like branded drug.
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